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Procoagulant constituents from Cordyceps militaris
來源:食品科學(xué)網(wǎng) 閱讀量: 496 發(fā)表時(shí)間: 2019-09-25
作者: Juanjuan Zhanga,1, Wei Zhanga,1, Zhenhua Yina, Changqin Li b,?, Wenyi Kanga,b,?
關(guān)鍵詞: Cordyceps militaris,Chemical component,Procoagulant activity,Ergosterol
摘要:

Cordyceps militaris, belongs to Clavicipitaceae family, was investigated for its chemical compounds,

and six compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20

and recrystallization, and their structures were elucidated by spectral techniques and physicochemical

properties as ergosterol (1), adenosine (2), cordycepin (3), ergosterol peroxide (4), tetracosanoic acid

2,3-dihydroxypropylester (5), mannitol (6). Procoagulant activity was screened by assaying the activated

partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB)

in vitro. The results indicated that ergosterol, adenosine, cordycepin, ergosterol peroxide and mannitol

showed strong procoagulant activity.

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